2024 Author: Harry Day | [email protected]. Last modified: 2023-12-17 15:43
Scientists at the University of Oxford (the real British scientists) summarized the results of 522 studies, including 164,477 participants - men and women 18 years and older who suffered from depression and received antidepressants for 8 weeks - the time that guarantees the onset of antidepressant action.
Despite the fact that this is the largest scientific work in this area, the editors notes that most of the 522 studies included in the analysis were funded by pharmaceutical companies. About 9% of them were identified by researchers as having a high risk of distorting the results.
Scientists found that all types of antidepressants tested were more effective in reducing the complex of symptoms associated with depression than placebo (drug without active ingredient). The doctrine found that drugs improve the condition of patients by 50% or more.
Despite the fact that all drugs in this study were found to be more effective than placebo, there was a significant difference in the effectiveness of different antidepressants.
The drugs that have been found to be the most effective in treating depression are:
Agomelatine (Valdoxan, Melitor, Thymanax (Agomelatine (Valdoxan, Melitor Timanax)
Amitriptyline (Elatrol, Elatrolet)
Amitriptyline (Elatrol, Elatrolet)
Escitalopram (Cipralex, Esto)
Escitalopram (Cipralex, Esto)
Mirtazapine (Miro, Remeron)
Mirtazepine (Miro, Remeron)
Paroxetine (Seroxat, Paxil)
Paroxetine (Seroxat, Paxil)
Venlafaxine (Effexor)
Venlafaxine (Effexor)
Vortioxetine (Trintellix. Brintellix (Vortioxetine (Trintellix, Brintellix)
The drugs with the least effectiveness:
Fluoxetine (Prozac)
Fluoxetine (Prozac)
Fluvoxamine (Favoxil)
Fluvoxamine (Favoxil)
Reboxetine (Edronax)
Riboxetine (Adronax)
Trazodone
Trazodone
Scientists assessed the degree of drug response to patients based on patient withdrawal from each study before eight weeks had elapsed. This phenomenon in most cases occurs due to side effects that patients are not able to tolerate or due to low efficiency.
While antidepressants are the most common treatment for depression, they are, of course, imperfect. An estimated one third of patients do not respond to drug therapy. And if the drug works, then its effect becomes noticeable only after 4-8 weeks.
Despite the effectiveness of antidepressants, many depressed patients do not seek help or receive medication or psychotherapy. One of the most recent published studies, which involved 240 people, found that only a third of people diagnosed with depression were receiving therapy.
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